Question Your World: Can Gene Editing Stop HIV?

Posted: July 19, 2019

As technology continues to expand so does the potential of helping those that are suffering from diseases worldwide. The impacts of science and technology on the medical field continue to change the way we live and also the way we get treatment for various illnesses. The big and scary diseases like cancer and HIV still cause much suffering and strain on millions of people, but perhaps new breakthroughs in science could one day address those concerns. Can gene editing stop HIV? 

Animal testing in science is often a controversial topic. A cutting-edge gene editing technique, known as CRISPr-Cas9, has also been a controversial topic. However, some recent news involving these topics is giving scientists a hopeful look at the future. 

A team of researchers just announced that by using CRISPr alongside a potent HIV suppressant, they have nearly eradicated HIV from cells in mice and have thus prevented it from spreading through the body.  

Image credit: Getty Images

This experiment required three different approaches. First they tested cells in a lab just to see if they could, in fact, edit these cells to shut down HIV when not in a living system. Then they infected mice with HIV to see if they could edit the genes in a living system. Lastly the mice were given human cells that contained HIV. 

In all three cases, the CRISPr gene editing plan enhanced the ability to reduce the virus' presence and ability to replicate. In fact, in 9 of the 23 mice included in the study, the virus was undetectable as much as 8 weeks after treatment ended. 

This was the preliminary test and much more work is needed to better understand how this would impact the living system beyond this experiment, in things such as monkeys or even humans. Right now over 36 million people have HIV.  This seemingly unstoppable disease has caused much suffering in patients and for their loved ones as well. 

At the end of 2018, a pretty huge story made headlines all across the globe. A researcher claimed to have birthed the first human baby that had edited genes, to prevent HIV from ever being able to exist in that body. Those headlines were soon examined and unfortunately debunked as a hoax. That news story highlights how important the intersection of health and science are. The research on the mice has been peer reviewed and is a real first step towards the goal of finding a cure for what is currently known as an unstoppable disease. 

While gene editing technology continues to draw skepticism, breakthroughs like these show promise that, with enough research, funding, and community support, science may be able to help people that currently have no hope for a long-term solution. More research will continue, stay tuned as details develop.